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The rationale for treating features of the upper motor neurone syndrome must be better understood and sensitive, validated spasticity measures need to be developed.

On investigation the lower limbs showed an up-per motor neurone type of lesion with complete loss of power, Brisk knee and ankle-jerks, absent abdominal reflexes, and Bilateral extensor plantar response.

After studying physics at Oxford University, Hawking had begun his first year of research work at Cambridge when he was diagnosed with motor neurone disease.

Objective To investigate the clinical relevance of serum level of neurone specific enolase (NSE) in patients with cerebral infarction.