Youcanaskhimagainifyoulike,butitwon’tmakeany

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You can ask him again if you like, but it won’t make any _______ —he’ll still say no.

A. adjustment B. decision

C. contribution D. difference

解析：选D。考查make 短语辨析。make some/much/no/little difference 意为“有一些/有很大/没有/几乎没有影响/关系”； make an adjustment调整；make a decision做决定; make a contribution做贡献，故选D。